Investigation of serum galanin, alarin, meteorin-like protein, and ischemia modified albumin levels in patients with schizophrenia

• Published in: Acta neuropsychiatrica 2024-12, Vol.36 (6), p.485-494
• Main Authors: Gul, Ozlem, Gul, Huseyin Fatih, Parsanoglu, Zozan, Balaban, Ozlem Devrim
• Format: Article
• Language: English
• Subjects: Biochemistry; Biomarkers; Chronic obstructive pulmonary disease; Diabetes; Drug use; Epilepsy; Hospitals; Hypertension; Hypotheses; Infectious diseases; Ischemia; Mental depression; Mental disorders; Mental health; Multiple sclerosis; Neuropeptides; Original Article; Pathophysiology; Patients; Peptides; Proteins; Remission (Medicine); Rheumatoid arthritis; Schizophrenia; Substance use disorder
• ISSN: 0924-2708; 1601-5215
• DOI: 10.1017/neu.2024.20

Objective:The objective of the current research is to study the serum levels of ischemia modified albumin (IMA), a new oxidative stress indicator, and various peptides (galanin, alarin, and meteorin-like protein) that may affect the pathophysiology of schizophrenia, determine their relationship with clinical features and each other, and compare them to those in healthy controls.Materials and Methods:This is a cross-sectional study consisting of 45 individuals with schizophrenia who are in remission and 45 healthy individuals. The differences and relationships between categorical variables and serum protein levels of the patient and control groups were statistically analysed. Receiver operating characteristics analysis was used for the diagnostic decision-making properties of serum protein levels to predict the presence of the disease.Results:In comparison with the control group, the median levels of serum proteins galanin and alarin were statistically lower in the patient group, whereas METRNL and IMA levels were higher. Considering the predictive values of serum proteins in the diagnosis of the disease, it was observed that serum galanin, alarin, and IMA levels had a sensitivity and specificity higher than 80%, followed by METRNL with 73.3% sensitivity and 66.7% specificity.Conclusion:Our findings reveal galanin, alarin, meteorin-like protein, and IMA are important molecules with high sensitivity and specificity in diagnosing schizophrenia. Furthermore, we think that further studies are needed to use them as reliable parameters in terms of clinical course, classification, and prognosis in explaining the etiopathogenesis of the disease.