BioFire[sup.®] Joint Infection Panel for Samples Other than Synovial Fluid

Objectives: The early identification of infection-causing microorganisms through multiplex PCR panels enables prompt and targeted antibiotic therapy. This study aimed to assess the performance of the BioFire[sup.®] Joint Infection Panel (BF-JIP) in analysing non-synovial fluid samples. Methods: We c...

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Bibliographic Details
Published in:Antibiotics (Basel) 2024-12, Vol.13 (12), p.1198
Main Authors: Benvenuto, Nicola, Di Bella, Stefano, Principe, Luigi, Luppino, Diego, Conti, Jacopo, Costantino, Venera, Di Santolo, Manuela, Busetti, Marina, Luzzati, Roberto, Zerbato, Verena
Format: Article
Language:English
Subjects:
Abscesses
Accuracy
Agreements
Antibiotics
Antimicrobial agents
Bacteria
BioFire® Joint Infection Panel
Breast implants
Cerebrospinal fluid
Comorbidity
culture-based diagnosis
diagnosis
diagnostic microbiology
Drug resistance
Encephalitis
Gram-negative bacteria
Gram-positive bacteria
Health aspects
Infection
Infections
Infectious diseases
Joint diseases
Medical records
Meningitis
Microorganisms
multiplex PCR panels
Pathogens
Patients
Performance assessment
Performance evaluation
Surgical drains
Synovial fluid
Wound drainage
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Summary:Objectives: The early identification of infection-causing microorganisms through multiplex PCR panels enables prompt and targeted antibiotic therapy. This study aimed to assess the performance of the BioFire[sup.®] Joint Infection Panel (BF-JIP) in analysing non-synovial fluid samples. Methods: We conducted a retrospective cohort study at Trieste University Hospital, Italy, on hospitalised adults with non-synovial fluid samples tested by both BF-JIP and traditional culture methods (November 2022–April 2024). Results: We evaluated 48 samples from 45 patients, including 24 abscess drainage fluids and 10 tissue samples. The BF-JIP showed high concordance (85.4%) and enhanced detection (4.3%) compared to culture methods. The BF-JIP excelled in cerebrospinal fluid (CSF) (100% accuracy and concordance) and in abscess drainage fluid (accuracy: 95.8%; concordance: 91.7%) identification and maintained high performance rates in patients under antibiotics. Conclusions: These findings suggest that BF-JIP is a valuable tool for accurate pathogen detection in various clinical samples, offering the additional advantage of being a rapid method.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics13121198