The VEGFA rs2010963 Gene Polymorphism Is a Potential Genetic Risk Factor for Myocardial Infarction in Slovenian Subjects with Type 2 Diabetes Mellitus

Coronary artery disease (CAD) is a life-threatening condition caused by the chronic gradual narrowing of the lumen of the blood vessels of the heart by atherosclerotic plaque with a strong genetic component. The aim of our study was to investigate the association between the VEGFA polymorphism rs201...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2024-12, Vol.14 (12), p.1584
Main Authors: Grbić, Emin, Letonja, Jernej, Petrovič, Danijel
Format: Article
Language:English
Subjects:
Alleles
Angina pectoris
Arteriosclerosis
Atherosclerosis
Blood vessels
Cardiovascular disease
Cholesterol
Coronary artery disease
Creatinine
Diabetes
Diabetes mellitus (non-insulin dependent)
Gene polymorphism
Genes
Genetic aspects
Genetic polymorphisms
Health risk assessment
Heart attack
Heart attacks
Heart diseases
Hemoglobin
Ischemia
Kinases
Myocardial infarction
Polymorphism
Proteins
Risk factors
rs2010963
Statistical analysis
T2DM
Type 2 diabetes
Vascular endothelial growth factor
VEGFA
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Summary:Coronary artery disease (CAD) is a life-threatening condition caused by the chronic gradual narrowing of the lumen of the blood vessels of the heart by atherosclerotic plaque with a strong genetic component. The aim of our study was to investigate the association between the VEGFA polymorphism rs2010963 and myocardial infarction in patients with type 2 diabetes, as well as the expression of VEGFA. A total of 1589 unrelated Caucasians with T2DM lasting longer than 10 years were divided into two groups: case group subjects with MI (484) and a control group without a history of CAD (1105). A total of 25 endarterectomy sequesters were immunohistochemically stained to assess VEGFA expression. The rs2010963 polymorphism of the VEGFA gene was genotyped using a KBioscience Ltd. competitive allele-specific fluorescence-based PCR (KASPar) assay. The C allele was significantly more common in the case group according to the dominant model of inheritance (CC + CG vs. GG) (OR: 1.32; 95% CI: 1.05–1.66; p = 0.0197). A statistically significantly higher numerical areal density of VEGFA-positive cells was found in subjects with the C allele (CC + CG genotypes) in comparison to the GG genotype (117 ± 35/mm[sup.2] vs. 58 ± 21/mm[sup.2]; p < 0.001). To conclude, the rs2010963 polymorphism is a potential genetic risk factor for myocardial infarction in Slovenian patients with T2DM.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom14121584