Peroxisome Proliferator Activator α Agonist Clofibrate Induces Pexophagy in Coconut Oil-Based High-Fat Diet-Fed Rats

Toxicologists know that peroxisome proliferator-activated receptors α agonists can induce peroxisomal proliferation in the liver of rodents but do not know whether pexophagy follows peroxisome proliferation. We showed that clofibrate, a peroxisome proliferator-activated receptors α agonist, induced...

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Published in:Biology (Basel, Switzerland) Switzerland), 2024-12, Vol.13 (12), p.1027
Main Authors: Ohshima, Kanami, Hara, Emika, Takimoto, Mio, Bai, Yidan, Hirata, Mai, Zeng, Wen, Uomoto, Suzuka, Todoroki, Mai, Kobayashi, Mio, Kozono, Takuma, Kigata, Tetsuhito, Shibutani, Makoto, Yoshida, Toshinori
Format: Article
Language:English
Subjects:
Agonists
Animals
Autophagy
Biosynthesis
Cholesterol
Clofibrate
Coconut oil
Coronary vessels
Diet
Fatty acids
Fenofibrate
Hepatectomy
High fat diet
Inflammation
Lipids
Liver
Metabolism
Metabolites
Nutrition research
Oxidation
Peroxisome proliferator-activated receptors
Pexophagy
Proteins
steatosis
Water supply
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Summary:Toxicologists know that peroxisome proliferator-activated receptors α agonists can induce peroxisomal proliferation in the liver of rodents but do not know whether pexophagy follows peroxisome proliferation. We showed that clofibrate, a peroxisome proliferator-activated receptors α agonist, induced pexophagy in the high-fat diet-fed rats through the pexophagy regulators. These novel findings suggested that rodent peroxisome proliferation with peroxisome proliferator-activated receptors α agonists is useful for understanding the biology of pexophagy in mammals and impacts the research on selected autophagy.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology13121027