Copper‐Catalyzed Cross Coupling Reaction of Alkyl Bromides with (DMPU)2Zn(Rf)2 Reagent: A Method for the Synthesis of Perfluoroalkylated Compounds

A method for the copper‐catalyzed cross‐coupling of alkyl bromides with a range of (DMPU)2Zn(Rf)2 reagents has been developed. This protocol tolerates multiple functional groups and provides broad access to aliphatic perfluoroalkylated compounds. The applicability of this procedure is demonstrated i...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2024-12, Vol.366 (24), p.5001-5007
Main Authors: Liu, Bosheng, Jiang, Xujuan, Song, Yanshan, Liu, Shiwen, Xiong, Xiaodong, Zeng, Xiaojun
Format: Article
Language:English
Subjects:
Alkyl bromides
Bromides
Chemical reactions
Chemical synthesis
Copper
Copper catalysis
Cross coupling
Fluoroalkylation
Functional groups
Reagents
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Summary:A method for the copper‐catalyzed cross‐coupling of alkyl bromides with a range of (DMPU)2Zn(Rf)2 reagents has been developed. This protocol tolerates multiple functional groups and provides broad access to aliphatic perfluoroalkylated compounds. The applicability of this procedure is demonstrated in the late‐stage functionalization of drug analogues.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202400905