De Novo Construction of pKa‐Tunable Xanthene Molecules for pH Sensitive Fluorescence Navigation

pH is spatiotemporal variable dynamically in physiological and pathological processes, and the tiny pH changes can result completely different physiological processes. However, the major drawbacks of conventional pH‐activatable probes are their large acid‐base transition width and the challenge to a...

Full description

Saved in:
Bibliographic Details
Published in:Advanced functional materials 2025-01, Vol.35 (2), p.n/a
Main Authors: Zhang, Li‐Na, Chen, Shan‐Yong, Shi, Lei, Ran, Xiao‐Yun, Zhang, Hong, Moon, Huiyeon, Lee, Yubin, Yu, Xiao‐Qi, Kim, Jong Seung, Li, Kun
Format: Article
Language:English
Subjects:
fluorescence navigation
fluorescent probe
Physiology
pKa‐tunable
surgical resection
Tumors
xanthene derivative
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:pH is spatiotemporal variable dynamically in physiological and pathological processes, and the tiny pH changes can result completely different physiological processes. However, the major drawbacks of conventional pH‐activatable probes are their large acid‐base transition width and the challenge to adjust their pKa suitable for various application. In response to these issues, a novel approach is proposed to realize sensitive response and a general strategy to construct a multicolor and pKa‐tunable xanthene‐based platform. In these probes, the narrowest acid‐base transition range is just 1 pH units, achieved by introducing the electron‐rich pyridine as ingenious proton catcher. Especially, Si‐4Py owns near‐infrared (NIR) signal and pKa of 5.56, which is successfully used for the rapid and high‐contrast imaging of distal metastatic tumors. This has significant implications for guiding surgeons in the removal of these tumors and ultimately improve patient outcomes. Additional, the sustainably innovative strategy proposed by this work can serve as effective reference in pH probe development. A novel strategy to develop multicolor and pKa‐tunable xanthene‐based probes with narrow acid‐base transition ranges is constructed by introducing electron‐rich pyridine as ingenious proton catcher, which is successful used for rapid and high‐contrast imaging of the distal metastatic tumor and fluorescence‐guided surgery.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202412595