Non-adherence, discontinuation, and seroconversion among people on daily HIV pre-exposure prophylaxis (PrEP) in Brazil: a nationwide cohort study

The goal of this study was to evaluate characteristics associated with Pre-exposure Prophylaxis for HIV infection (PrEP) non-adherence or discontinuation in Brazil and assess the association between these outcomes and HIV seroconversion. We used linked national dispensing and pathology data to ident...

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Bibliographic Details
Published in:AIDS care 2025-02, Vol.37 (2), p.289-299
Main Authors: Crepalde-Ribeiro, Kennedy, Braga, Maria das Graças, Silveira, Micheline Rosa, Moura, Alexandre Sampaio, Vaz-de-Melo, Pedro O.S., Ferraz, Matheus Marchesotti Dutra, Pearson, Sallie-Anne, Costa, Juliana de Oliveira
Format: Article
Language:English
Subjects:
Adherence
Adherents
Adolescent
Adult
Anti-HIV Agents - therapeutic use
Brazil - epidemiology
Cohort analysis
Cohort Studies
Discontinued
Disease prevention
Female
HIV
HIV Infections - drug therapy
HIV Infections - prevention & control
HIV prevention
HIV seroconversion
HIV Seropositivity
Human immunodeficiency virus
Humans
Male
Medication Adherence
Middle Aged
Pathology
Pre-exposure prophylaxis
Pre-Exposure Prophylaxis - statistics & numerical data
Prophylaxis
Regression analysis
Regression models
SDG 3: Good health and wellbeing and SDG 10: reduced inequalities
Seroconversion
Women
Young Adult
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Summary:The goal of this study was to evaluate characteristics associated with Pre-exposure Prophylaxis for HIV infection (PrEP) non-adherence or discontinuation in Brazil and assess the association between these outcomes and HIV seroconversion. We used linked national dispensing and pathology data to identify people aged 14+ years initiating PrEP in 2018. We estimated non-adherence using the proportion of days covered (PDC), defining non-adherence as PDC 
ISSN:0954-0121
1360-0451
1360-0451
DOI:10.1080/09540121.2024.2443824