Quercetin administration reduces the pro-inflammatory cytokines expression in cirrhotic rats

The flavonoid quercetin significantly lowered serum ALT, AST and ALP activities (indicators of hepatocellular damage) and consistently caused a reduction of mRNA levels of TGF-α, TNF-α and IL-6, in treated cirrhotic animals compared with untreated CBDL rats. [...] quercetin treatment, initiated fo...

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Bibliographic Details
Published in:Proceedings of the Nutrition Society 2010, Vol.69 (OCE3), Article E259
Main Authors: Culebras, J. M., Tieppo, J., Cuevas, M. J., Vercelino, R., González-Gallego, J., Marroni, N., Tuñón, M. J.
Format: Article
Language:English
Subjects:
Animals
Citrus fruits
Liver cirrhosis
Molecular weight
Rodents
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Summary:The flavonoid quercetin significantly lowered serum ALT, AST and ALP activities (indicators of hepatocellular damage) and consistently caused a reduction of mRNA levels of TGF-α, TNF-α and IL-6, in treated cirrhotic animals compared with untreated CBDL rats. [...] quercetin treatment, initiated following the establishment of liver injury in cirrhotic animals, has a clear anti-inflammatory effect in the subsequent severity of the CBDL-related inflammation.
ISSN:0029-6651
1475-2719
DOI:10.1017/S0029665110000480