Morphofunctional Evaluation of the Effect of Collagen-1-Based Dressing on Skin Regeneration after Burn Trauma in Mice of Two Genetic Strains

Morphofunctional evaluation of the effect of biological dressing with collagen-1 on healing of 3A degree burn wound in outbred and mutant Hr hrHrhr (hairless) mice was carried out by the histological method and optic radioautography. A pronounced stimulatory effect of the dressing on skin regenerati...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2010-07, Vol.149 (1), p.154-160
Main Authors: Kolokolchikova, E. G, Zhirkova, E. A, Golovatenko-Abramov, P. K, Platonov, E. S, Botcharova, V. S, Khvatov, V. B
Format: Article
Language:English
Subjects:
Analysis
Animals
Autoradiography
biological dressing
Biological Dressings
Biomedical and Life Sciences
Biomedicine
Burns - therapy
Burns and scalds
Cell Biology
Cell Proliferation
Collagen
Collagen Type I - therapeutic use
Epithelial Cells - cytology
hair follicle
hairlessHrhrHrhrmice
Internal Medicine
Laboratory Medicine
Mice
Mice, Hairless
Pathology
Regeneration - physiology
Skin
Skin Physiological Phenomena
skin regeneration
stem cell
Stem cells
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
Wound Healing - drug effects
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Summary:Morphofunctional evaluation of the effect of biological dressing with collagen-1 on healing of 3A degree burn wound in outbred and mutant Hr hrHrhr (hairless) mice was carried out by the histological method and optic radioautography. A pronounced stimulatory effect of the dressing on skin regeneration in mice was demonstrated. According to radioautography data, early dressing of the burn wounds in Hr hr hrmice led to active proliferation of epithelial cells in dermal cyst and vascular endotheliocytes. The possible mechanisms of the stimulatory effect of collagen-based dressing on wound healing are discussed.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0896-1