FatalScedosporium prolificans infection in a leukemic patient

The case is described of a 42-year-old patient with acute myeloid leukemia who received two courses of chemotherapy complicated by prolonged bone marrow depression. He was admitted to hospital with fever, hepatosplenomegaly and bilateral nodular pulmonary infiltrates. After admission diffuse cutaneo...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 1997-06, Vol.16 (6), p.460-464
Main Authors: Feltkamp, M. C. W., Kersten, M. J., Lelie, J., Burggraaf, I. D., Hoog, G. S., Kuijper, E. J.
Format: Article
Language:English
Subjects:
Bone marrow
Leukemia
Medical diagnosis
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Summary:The case is described of a 42-year-old patient with acute myeloid leukemia who received two courses of chemotherapy complicated by prolonged bone marrow depression. He was admitted to hospital with fever, hepatosplenomegaly and bilateral nodular pulmonary infiltrates. After admission diffuse cutaneous skin nodules, and hypodense lesions in the hemispheres and cerebellum developed. Cultures of cerebrospinal fluid, bronchoalveolar lavage fluid, skin biopsy specimens and blood revealedScedosporium prolificans, indicative of disseminated mycosis. Treatment with amphotericin B and fluconazole was unsuccessful and the patient died within five days after admission. Features that may enhance early recognition ofScedosporium prolificans infection by both clinicians and microbiologists, as well as options in the treatment of infection with this fungal agent are discussed.[PUBLICATION ABSTRACT]
ISSN:0934-9723
1435-4373
DOI:10.1007/BF02471912