Spared Retention of Inhibitory Avoidance Learning After Posttraining Amygdala Lesions

• Published in: Behavioral neuroscience 1995-08, Vol.109 (4), p.803-807
• Main Authors: Parent, Marise B, Quirarte, Gina L, Cahill, Larry, McGaugh, James L
• Format: Article
• Language: English
• Subjects: Amygdala; Amygdala - physiology; Anatomical correlates of behavior; Animal; Animal memory; Animals; Avoidance Conditioning; Avoidance Learning - physiology; Behavioral psychophysiology; Biological and medical sciences; Brain; Brain Mapping; Fear - physiology; Fundamental and applied biological sciences. Psychology; Learning; Male; Memory; Motivation; Neural Inhibition - physiology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate - physiology; Retention (Psychology) - physiology; Rodents; Shock
• ISSN: 0735-7044; 1939-0084
• DOI: 10.1037/0735-7044.109.4.803

Previous findings indicate that the memory-impairing effects of posttraining amygdala lesions are attenuated by increasing the number of training trials given prior to the induction of the lesion. The aim of this experiment was to determine whether the degree of impairment is also influenced by the footshock intensity used during training. Rats were given 1 trial of inhibitory avoidance (IA) training with either no footshock or a footshock at 1 of 3 intensities. Sham or neurotoxic amygdala lesions were induced 1 week later. On a retention test performed 4 days after surgery, the performance of all amygdala-lesioned rats given footshock training, including those given the lowest training footshock, was better than that of amygdala-lesioned rats given no training footshock. These findings of preserved retention of IA learning in rats given posttraining amygdala lesions do not support a general hypothesis that the amygdala is a locus of permanent changes underlying aversively motivated learning.