Oral Cocaine Self-Administration in Rhesus Monkeys: Strategies for Engendering Reinforcing Effects

Orally delivered cocaine was established as a reinforcer for 8 rhesus monkeys ( Macaca mulatta ). Initially, each monkey was given a choice between the water vehicle and a 0.2 mg/ml cocaine concentration. The 0.2 mg/ml solution was not consumed in preference to water. One or more acquisition procedu...

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Bibliographic Details
Published in:Experimental and clinical psychopharmacology 1995-05, Vol.3 (2), p.129-139
Main Authors: Macenski, Mitchell J, Meisch, Richard A
Format: Article
Language:English
Subjects:
Animal
Cocaine
Monkeys
Self-Reinforcement
Self-Stimulation
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Summary:Orally delivered cocaine was established as a reinforcer for 8 rhesus monkeys ( Macaca mulatta ). Initially, each monkey was given a choice between the water vehicle and a 0.2 mg/ml cocaine concentration. The 0.2 mg/ml solution was not consumed in preference to water. One or more acquisition procedures were used with each monkey to establish orally delivered cocaine as a reinforcer. A common feature of all but one procedure was environmental situations that lead to the elective drinking of the cocaine solution. Evidence confirming the establishment of cocaine's reinforcing effects was obtained by testing each monkey across a broad range of cocaine concentrations under conditions of concurrent access to the cocaine solution and vehicle. Over a range of concentrations, the monkeys obtained greater cocaine than vehicle deliveries.
ISSN:1064-1297
1936-2293
DOI:10.1037/1064-1297.3.2.129