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Dopaminergic mechanisms in idiopathic and drug-induced psychoses
Stimulant drugs such as cocaine and amphetamine are among the most commonly abused substances by schizophrenic patients. This may be due in part to aspects of the illness and treatment side effects that impel patients to use dopamine agonist drugs. Dopaminergic neural systems have been shown to medi...
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| Published in: | Schizophrenia bulletin 1990, Vol.16 (1), p.97-110 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c357t-acc1c62568f853f49b8ae9ab05b243d8e0ad7d0e72ca738bd8da80298f77ce2c3 |
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| container_end_page | 110 |
| container_issue | 1 |
| container_start_page | 97 |
| container_title | Schizophrenia bulletin |
| container_volume | 16 |
| creator | Lieberman, J A Kinon, B J Loebel, A D |
| description | Stimulant drugs such as cocaine and amphetamine are among the most commonly abused substances by schizophrenic patients. This may be due in part to aspects of the illness and treatment side effects that impel patients to use dopamine agonist drugs. Dopaminergic neural systems have been shown to mediate both stimulant drug effects and schizophrenia. Because of the hypothesized overlap in the pathophysiology of schizophrenia and the neurobiological effects of chronic stimulant use, the potential for serious complication of the primary disease by substance abuse exists. This article reviews the neurobiological mechanisms of behavioral sensitization and neurotoxicity associated with chronic stimulant administration in the context of pathophysiological theories of schizophrenia. Discussion focuses on the potential impact of stimulant use on the disease process as well as the manifest phenomenology and course of schizophrenia. |
| doi_str_mv | 10.1093/schbul/16.1.97 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0586-7614 |
| ispartof | Schizophrenia bulletin, 1990, Vol.16 (1), p.97-110 |
| issn | 0586-7614 1745-1701 |
| language | eng |
| recordid | cdi_proquest_journals_614430112 |
| source | APA PsycARTICLES |
| subjects | Amphetamine - adverse effects Animals Brain - drug effects CNS Stimulating Drugs Cocaine - adverse effects Dopamine Dopamine - physiology Dose-Response Relationship, Drug Human Humans Neurobiology Neurotoxicity Pathophysiology Psychoses, Substance-Induced - physiopathology Receptors, Dopamine - drug effects Schizophrenia Schizophrenia - physiopathology Schizophrenic Psychology Sensitization Substance-Related Disorders - physiopathology |
| title | Dopaminergic mechanisms in idiopathic and drug-induced psychoses |
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