Tardive Dyskinesia: Possible Involvement of Free Radicals and Treatment With Vitamin E

A decade ago a hypothesis introduced to explain tardive dyskinesia (TD) implicated free radicals generated secondary to neuroleptic treatment. Since then many preclinical and clinical studies have investigated this possibility. These studies suggest that free radicals are probably involved in the pa...

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Bibliographic Details
Published in:Schizophrenia bulletin 1999-01, Vol.25 (4), p.731-740
Main Authors: Elkashef, Ahmed M, Wyatt, Richard Jed
Format: Article
Language:English
Subjects:
Antioxidants - therapeutic use
Biological and medical sciences
Drug Therapy
Drug toxicity and drugs side effects treatment
Dyskinesia, Drug-Induced - complications
Dyskinesia, Drug-Induced - drug therapy
Dyskinesia, Drug-Induced - metabolism
Free Radicals - metabolism
Human
Humans
Medical sciences
Nerve Degeneration - complications
Nerve Degeneration - pathology
Neuroleptic Drugs
Pharmacology. Drug treatments
Tardive Dyskinesia
Toxicity: nervous system and muscle
Vitamin E - therapeutic use
Vitamin Therapy
Vitamins
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Summary:A decade ago a hypothesis introduced to explain tardive dyskinesia (TD) implicated free radicals generated secondary to neuroleptic treatment. Since then many preclinical and clinical studies have investigated this possibility. These studies suggest that free radicals are probably involved in the pathogenesis of TD and that vitamin E could be efficacious in its treatment.
ISSN:0586-7614
1745-1701
DOI:10.1093/oxfordjournals.schbul.a033414