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TRPV5 and TRPV6 in Ca2+ (re)absorption: regulating Ca2+ entry at the gate
Issue Title: Functional Role of TRP Channels Many physiological functions rely on the exact maintenance of body Ca^sup 2+^ balance. Therefore, the extracellular Ca^sup 2+^ concentration is tightly regulated by the concerted actions of intestinal Ca^sup 2+^ absorption, exchange of Ca^sup 2+^ to and f...
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Published in: | Pflügers Archiv 2005-10, Vol.451 (1), p.181-192 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Issue Title: Functional Role of TRP Channels Many physiological functions rely on the exact maintenance of body Ca^sup 2+^ balance. Therefore, the extracellular Ca^sup 2+^ concentration is tightly regulated by the concerted actions of intestinal Ca^sup 2+^ absorption, exchange of Ca^sup 2+^ to and from bone, and renal Ca^sup 2+^ reabsorption. Renal distal convoluted and connecting tubular cells as well as duodenal epithelial cells are unique in their ability to mediate transcellular (re)absorption of Ca^sup 2+^ at large and highly variable rates. Two members of the transient receptor potential (TRP) superfamily, TRP vanilloid (TRPV)5 and TRPV6, are specialized epithelial Ca^sup 2+^ channels responsible for the critical Ca^sup 2+^ entry step in transcellular Ca^sup 2+^ (re)absorption in intestine and kidney, respectively. Because transcellular Ca^sup 2+^ transport is fine-tuned to the body's specific requirements, regulation of the transmembrane Ca^sup 2+^ flux through TRPV5/6 is of particular importance and has, therefore, to be conspicuously controlled. We present an overview of the current knowledge and recent advances concerning the coordinated regulation of Ca^sup 2+^ influx through the epithelial Ca^sup 2+^ channels TRPV5 and TRPV6 in transcellular Ca^sup 2+^ (re)absorption.[PUBLICATION ABSTRACT] |
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ISSN: | 0031-6768 1432-2013 |
DOI: | 10.1007/s00424-005-1430-6 |