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TRPV5 and TRPV6 in Ca2+ (re)absorption: regulating Ca2+ entry at the gate

Issue Title: Functional Role of TRP Channels Many physiological functions rely on the exact maintenance of body Ca^sup 2+^ balance. Therefore, the extracellular Ca^sup 2+^ concentration is tightly regulated by the concerted actions of intestinal Ca^sup 2+^ absorption, exchange of Ca^sup 2+^ to and f...

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Bibliographic Details
Published in:Pflügers Archiv 2005-10, Vol.451 (1), p.181-192
Main Authors: Nijenhuis, Tom, Hoenderop, Joost G. J., Bindels, René J. M.
Format: Article
Language:English
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Summary:Issue Title: Functional Role of TRP Channels Many physiological functions rely on the exact maintenance of body Ca^sup 2+^ balance. Therefore, the extracellular Ca^sup 2+^ concentration is tightly regulated by the concerted actions of intestinal Ca^sup 2+^ absorption, exchange of Ca^sup 2+^ to and from bone, and renal Ca^sup 2+^ reabsorption. Renal distal convoluted and connecting tubular cells as well as duodenal epithelial cells are unique in their ability to mediate transcellular (re)absorption of Ca^sup 2+^ at large and highly variable rates. Two members of the transient receptor potential (TRP) superfamily, TRP vanilloid (TRPV)5 and TRPV6, are specialized epithelial Ca^sup 2+^ channels responsible for the critical Ca^sup 2+^ entry step in transcellular Ca^sup 2+^ (re)absorption in intestine and kidney, respectively. Because transcellular Ca^sup 2+^ transport is fine-tuned to the body's specific requirements, regulation of the transmembrane Ca^sup 2+^ flux through TRPV5/6 is of particular importance and has, therefore, to be conspicuously controlled. We present an overview of the current knowledge and recent advances concerning the coordinated regulation of Ca^sup 2+^ influx through the epithelial Ca^sup 2+^ channels TRPV5 and TRPV6 in transcellular Ca^sup 2+^ (re)absorption.[PUBLICATION ABSTRACT]
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-005-1430-6