Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells

All-trans retinoic acid (ATRA) is a standard drug used for differentiation therapy in acute promyelocytic leukemia. To potentiate this therapy, we examined the effect of ellagic acid (EA), a natural polyphenolic compound with antiproliferative and antioxidant properties, on the growth and differenti...

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Bibliographic Details
Published in:International journal of hematology 2010-07, Vol.92 (1), p.136-143
Main Authors: Hagiwara, Yuki, Kasukabe, Takashi, Kaneko, Yasuhiko, Niitsu, Nozomi, Okabe-Kado, Junko
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Apoptosis - drug effects
Biological and medical sciences
Cell Differentiation - drug effects
Drug Synergism
Ellagic Acid - pharmacology
Flavonoids
Hematologic and hematopoietic diseases
Hematology
HL-60 Cells
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Medicine
Medicine & Public Health
Oncology
Original Article
Phenols
Polyphenols
Tretinoin - pharmacology
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Summary:All-trans retinoic acid (ATRA) is a standard drug used for differentiation therapy in acute promyelocytic leukemia. To potentiate this therapy, we examined the effect of ellagic acid (EA), a natural polyphenolic compound with antiproliferative and antioxidant properties, on the growth and differentiation of HL-60 acute myeloid leukemia cells. EA was found to induce apoptosis, which was blocked by pan-caspase inhibitor, Z-VAD-FMK. EA activated the caspase-3 pathway and enhanced the expressions of myeloid differentiation markers (CD11b, MRP-14 protein, granulocytic morphology) induced by ATRA treatment. These results indicate that EA is a potent apoptosis inducer and also effectively potentiates ATRA-induced myeloid differentiation of HL-60 cells.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-010-0627-4