Polymorphism of Glutathione S-Transferase (GST) Variants and Its Effect on Distribution of Urinary Arsenic Species in People Exposed to Low Inorganic Arsenic in Tap Water: An Exploratory Study

Glutathione S-tranferases (GST) are multigenic enzymes that have been associated with arsenic metabolism. The objective of this study was to evaluate the relationship between polymorphic variants of GST and urinary concentration of arsenic species in people exposed to low levels of arsenic. A cross-...

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Bibliographic Details
Published in:Archives of environmental & occupational health 2010-07, Vol.65 (3), p.140-147
Main Authors: Caceres, Dante D., Werlinger, Fabiola, Orellana, Magdalena, Jara, Marcelo, Rocha, Rene, Alvarado, Sergio A., Luis, Quiñones
Format: Article
Language:English
Subjects:
Arsenic
Arsenicals - metabolism
Arsenicals - urine
Chile
Cross-Sectional Studies
Drinking water
Environmental Exposure - adverse effects
exposure assessment
Female
genetic polymorphism
Genotype
Glutathione Transferase - genetics
Humans
Male
Polymerase Chain Reaction
Polymorphism, Genetic - genetics
risk assessment
Statistics, Nonparametric
Water Supply - analysis
Young Adult
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Summary:Glutathione S-tranferases (GST) are multigenic enzymes that have been associated with arsenic metabolism. The objective of this study was to evaluate the relationship between polymorphic variants of GST and urinary concentration of arsenic species in people exposed to low levels of arsenic. A cross-sectional study among 66 nonoccupationally exposed subjects, living in the city of Antofagasta, Chile. Polymorphic variants were analyzed by polymerase chain reaction (PCR) and arsenic species was determined by atomic absorption spectrometry. The effect of GST variants on arsenic concentration was evaluated using univariate and covariate-adjusted regressions. For both GSTT1 and GSTM1 there were no significant differences in detected arsenic relative species between carriers of the active and null polymorphic variants. There was nondefinitive evidence that polymorphic variants of GST play a role in arsenic metabolism in sample of the Chilean subjects studied.
ISSN:1933-8244
2154-4700
DOI:10.1080/19338240903390354