Does the Solid-Phase Synthesis of a Tetrapeptide Represent a Challenge at the Onset of the XXI Century? The Case of Cyclo [(3R)-3-hydroxydecanoyl-l-seryl-(3R)-3-hydroxydecanoyl-l-seryl]

At the beginning of the XXI century, 43 years after the description of the first solid-phase synthesis of a tetrapeptide by Bruce Merrifield, the synthesis of a tetrapeptide may still represent a synthetic challenge. This is the case of serratamolide, a cyclic tetradepsipeptide originally found in a...

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Published in:International journal of peptide research and therapeutics 2007-06, Vol.13 (1-2), p.313-327
Main Authors: Teixidó, Meritxell, Caba, Josep Maria, Prades, Roger, Zurita, Esther, Martinell, Marc, Vilaseca, Marta, Albericio, Fernando, Giralt, Ernest
Format: Article
Language:English
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Biosynthesis
Chemotherapy
Peptides
Pharmacology
Solid phase methods
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container_issue 1-2
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container_title International journal of peptide research and therapeutics
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creator Teixidó, Meritxell
Caba, Josep Maria
Prades, Roger
Zurita, Esther
Martinell, Marc
Vilaseca, Marta
Albericio, Fernando
Giralt, Ernest
description At the beginning of the XXI century, 43 years after the description of the first solid-phase synthesis of a tetrapeptide by Bruce Merrifield, the synthesis of a tetrapeptide may still represent a synthetic challenge. This is the case of serratamolide, a cyclic tetradepsipeptide originally found in a culture of Serratia marcescens, which exhibits interesting properties as a chemotherapeutic agent. Here we explore several methodologies for the synthesis of serratamolide in order to find a strategy that allows its preparation for further biological studies.
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subjects Biosynthesis
Chemotherapy
Peptides
Pharmacology
Solid phase methods
title Does the Solid-Phase Synthesis of a Tetrapeptide Represent a Challenge at the Onset of the XXI Century? The Case of Cyclo [(3R)-3-hydroxydecanoyl-l-seryl-(3R)-3-hydroxydecanoyl-l-seryl]
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