Establishment of the mimetic aging effect in mice caused by D-galactose

We successfully established an oxidant damage of mimetic aging model using mice induced by D-galactose, and the mimetic aging model is relative to free radical and the accumulation of waste substances in metabolism. The animals were divided into 3 groups: (1) phosphate-buffered saline (PBS); (2) 1%...

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Bibliographic Details
Published in:Biogerontology (Dordrecht) 2003, Vol.4 (1), p.15-18
Main Authors: HO, Shih-Ching, LIU, Jue-Hao, WU, Rey-Yih
Format: Article
Language:English
Subjects:
Aging
Aging - physiology
Animals
Antioxidants - metabolism
Biological and medical sciences
Biomarkers
Development. Metamorphosis. Moult. Ageing
Free radicals
Fundamental and applied biological sciences. Psychology
Galactose - chemistry
Galactose - metabolism
Male
Malondialdehyde - metabolism
Mice
Mice, Inbred C57BL
Oxidants - metabolism
Random Allocation
Superoxide Dismutase - metabolism
Thiobarbituric Acid Reactive Substances - metabolism
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:We successfully established an oxidant damage of mimetic aging model using mice induced by D-galactose, and the mimetic aging model is relative to free radical and the accumulation of waste substances in metabolism. The animals were divided into 3 groups: (1) phosphate-buffered saline (PBS); (2) 1% D-galactose; (3) 5% D-galactose by subcutaneous injection every day. After 45 days, mice treated with D-galactose showed a significant increase in the malondialdehyde (MDA), total antioxidant status (TAS) and a decrease in superoxide dismutase (SOD) in the blood compared with the PBS group. In the brain, the D-galactose treated mice exhibited a higher level MDA and a lower level SOD activity. In the liver, only the 5% D-galactose group indicated a significant increase in MDA. By reference to the oxidative biomarkers in blood, brain and liver, we have confirmed the reliability of the mimetic aging model.
ISSN:1389-5729
1573-6768
DOI:10.1023/A:1022417102206