Protective role of erdosteine on vancomycin-induced oxidative stress in rat liver

Drug-induced liver toxicity is a common cause of liver injury. This study was designed to elucidate whether high dose vancomycin (VCM) induces oxidative stress in liver and to investigate the protective effects of erdosteine, an expectorant agent. Twenty-two young Wistar rats were divided into three...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2006-10, Vol.291 (1-2), p.155-160
Main Authors: Sahin, Mehmet, Cam, Hakan, Olgar, Seref, Tunc, Sevket Ercan, Arslan, Cagatay, Uz, Efkan, Yilmaz, H Ramazan
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - toxicity
Antioxidants
Body weight
Catalase - metabolism
Expectorants - pharmacology
Injections, Intraperitoneal
Liver
Liver - drug effects
Male
Malondialdehyde - metabolism
Oxidative stress
Oxidative Stress - drug effects
Peroxidation
Protective Agents - pharmacology
Rats
Rats, Wistar
Rodents
Superoxide Dismutase - metabolism
Thioglycolates - pharmacology
Thiophenes - pharmacology
Vancomycin - toxicity
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Summary:Drug-induced liver toxicity is a common cause of liver injury. This study was designed to elucidate whether high dose vancomycin (VCM) induces oxidative stress in liver and to investigate the protective effects of erdosteine, an expectorant agent. Twenty-two young Wistar rats were divided into three groups as follows: control group, VCM, and VCM plus erdosteine. VCM was administered intraperitoneally in the dosage of 200 mg/kg twice daily for 7 days. Erdosteine was administered orally administered once a day at a dose of 10 mg/kg body weight. The activities of antioxidant enzymes such as superoxide dismutase and catalase as well as the concentration of malondialdehyde, as an indicator of lipid peroxidation, were measured to evaluate oxidative stress in homogenates of the liver. VCM administration increased malondialdehyde levels (p < 0.001), superoxide dismutase (p < 0.01) and catalase (p < 0.001) activities. Erdosteine co-administration with VCM injections caused significantly decreased malondialdehyde levels (p < 0.001), superoxide dismutase (p < 0.01) and catalase (p < 0.001) activities in liver tissue when compared with VCM alone. It can be concluded that erdosteine may prevent VCM-induced oxidative changes in liver by reducing reactive oxygen species.
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-006-9209-4