Effect of oral vanadyl sulfate treatment on serum enzymes and lipids of streptozotocin-diabetic young rats

In this work we investigate the possible toxicity of vanadyl sulfate (VOSO4), a compound capable of reducing hyperglycemia, on the following serum enzymes of diabetic young rats: alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LD) and creatine kinase (CK), as...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1999-08, Vol.198 (1/2), p.157-161
Main Authors: Pepato, M.T, Magnani, M.R.T, Kettlehut, I.C, Brunetti, I.L
Format: Article
Language:English
Subjects:
Administration, Oral
Alanine Transaminase - blood
Animals
Aspartate Aminotransferases - blood
Creatine Kinase - blood
diabetes mellitus
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - enzymology
drug therapy
insulin
insulin mimetics
Kinases
L-Lactate Dehydrogenase - blood
Lipids
Lipids - blood
Male
Muscles
Rats
Rats, Wistar
Rodents
Streptozocin
Sulfates
vanadium
Vanadium Compounds - administration & dosage
Vanadium Compounds - pharmacology
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Summary:In this work we investigate the possible toxicity of vanadyl sulfate (VOSO4), a compound capable of reducing hyperglycemia, on the following serum enzymes of diabetic young rats: alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LD) and creatine kinase (CK), as well as its effects on serum lipids. We find that at a concentration of 1 mg/mL VOSO4 has no toxic effect on the liver and muscles of diabetics young rats. These findings suggest that VOSO4 may be an alternative to insulin in the near future, due to its low cost, low toxicity and ready availability.
ISSN:0300-8177
1573-4919
DOI:10.1023/A:1006917007148