TMS1/ASC: the cancer connection

TMS1/ASC is a bipartite protein comprising two protein-protein interaction domains, a pyrin domain (PYD) and a caspase recruitment domain (CARD). Proteins containing these domains play pivotal roles in regulating apoptosis and immune response pathways, and mutations in a number of PYD- and CARD-cont...

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Bibliographic Details
Published in:Apoptosis (London) 2004-01, Vol.9 (1), p.5-18
Main Authors: McConnell, B B, Vertino, P M
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Breast cancer
Carcinogenesis
CARD Signaling Adaptor Proteins
Caspases - metabolism
Cell Nucleus - metabolism
Cytoskeletal Proteins - physiology
DNA Methylation
Enzyme Activation
Gene Silencing
Genome
Humans
Immune response
Inflammation
Medical research
Microscopy, Fluorescence
Models, Biological
Models, Genetic
Neoplasms - metabolism
Neoplasms - pathology
NF-kappa B - metabolism
Phylogeny
Protein Binding
Protein Structure, Tertiary
Proteins - chemistry
Proteins - physiology
Pyrin
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Summary:TMS1/ASC is a bipartite protein comprising two protein-protein interaction domains, a pyrin domain (PYD) and a caspase recruitment domain (CARD). Proteins containing these domains play pivotal roles in regulating apoptosis and immune response pathways, and mutations in a number of PYD- and CARD-containing proteins have been linked to autoinflammatory diseases and cancer. Indeed, one of the ways in which TMS1/ASC was identified was as a target of methylation-mediated silencing in breast cancer cells. This review discusses the mounting evidence supporting a correlation between the silencing of TMS1/ASC expression and cancer. In addition, it addresses the reported functions of TMS1/ASC that include apoptosis, activation of inflammatory caspases and regulation of NF-kappa B, and discusses the potential ways in which loss of TMS1/ASC contributes to carcinogenesis.
ISSN:1360-8185
1573-675X
DOI:10.1023/B:APPT.0000012117.32430.0c