Panosialins, inhibitors of an [alpha]1,3-fucosyltransferase Fuc-TVII, suppress the expression of selectin ligands on U937 cells

Panosialins A and B were isolated as inhibitors of an α1,3-fucosyltransferase, Fuc-TVII, which is a key enzyme in the biosynthesis of selectin ligands, from culture broth of Streptomyces sp. Panosialins A and B inhibited the Fuc-TVII activity with IC50 values of 4.8 and 5.3 μg/ml, respectively. Pano...

Full description

Saved in:
Bibliographic Details
Published in:Glycoconjugate journal 1998-11, Vol.15 (11), p.1079
Main Authors: Shinoda, Katsumi, Shitara, Kenya, Yoshihara, Yuko, Kusano, Akira, Uosaki, Youichi, Ohta, So, Hanai, Nobuo, Takahashi, Isami
Format: Article
Language:English
Subjects:
Biosynthesis
Cellular biology
Leukocytes
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Panosialins A and B were isolated as inhibitors of an α1,3-fucosyltransferase, Fuc-TVII, which is a key enzyme in the biosynthesis of selectin ligands, from culture broth of Streptomyces sp. Panosialins A and B inhibited the Fuc-TVII activity with IC50 values of 4.8 and 5.3 μg/ml, respectively. Panosialin A suppressed expression of selectin ligands on U937 cells, and inhibited the cell adhesion to immobilized E-selectin-immunoglobulin. Panosialins are the first reported Fuc-TVII inhibitors which can suppress the biosynthesis of selectin ligands and then inhibit selectin-mediated cell adhesion.[PUBLICATION ABSTRACT]
ISSN:0282-0080
1573-4986
DOI:10.1023/A:1006953626578