The catalytic mechanism of nucleoside diphosphate kinases

Nucleoside diphosphate kinases catalyze the reversible transfer of the gamma phosphate of nucleoside triphosphates to nucleoside diphosphates. This minireview presents recent advances in understanding the reaction mechanism using steady-state and fast kinetic studies, X-ray crystallography, and site...

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Bibliographic Details
Published in:Journal of bioenergetics and biomembranes 2000-06, Vol.32 (3), p.237
Main Authors: Lascu, I, Gonin, P
Format: Article
Language:English
Subjects:
Animals
Catalysis
Cations, Divalent
Enzyme Inhibitors - pharmacology
Enzymes
Humans
Kinetics
Metals
Nucleoside-Diphosphate Kinase - antagonists & inhibitors
Nucleoside-Diphosphate Kinase - metabolism
Nucleoside-Diphosphate Kinase - physiology
Phosphorylation
Proteins
Substrate Specificity
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Summary:Nucleoside diphosphate kinases catalyze the reversible transfer of the gamma phosphate of nucleoside triphosphates to nucleoside diphosphates. This minireview presents recent advances in understanding the reaction mechanism using steady-state and fast kinetic studies, X-ray crystallography, and site-directed mutagenesis. We also briefly discuss the physiological relevance of in vitro studies.
ISSN:0145-479X
1573-6881
DOI:10.1023/A:1005532912212