Nonsteroidal anti-inflammatory drugs: I. A study of “structure-efficacy of the anti-inflammatory effect relationship activity”

Using the computer system SARD-21 (Structure Activity Relationship & Design) structural features typical for the high-and low-effective nonsteroidal anti-inflammatory drugs (NSAIDs) have been recognized and the influence of these features on the anti-inflammatory properties have been evaluated....

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Bibliographic Details
Published in:Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2007-12, Vol.1 (4), p.305-312
Main Authors: Khayrullina, V. R., Mukhametov, A. D., Tjurina, L. A., Garifullina, G. G., Gerchikov, A. Ya, Zarudiy, Ph. S.
Format: Article
Language:English
Subjects:
Nonsteroidal anti-inflammatory drugs
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Summary:Using the computer system SARD-21 (Structure Activity Relationship & Design) structural features typical for the high-and low-effective nonsteroidal anti-inflammatory drugs (NSAIDs) have been recognized and the influence of these features on the anti-inflammatory properties have been evaluated. This information has been used for generation of the model for prediction of anti-inflammatory effectiveness of pharmaceutical preparations with 76% and 81% levels of recognition by two methods. The recognized structural parameters may be successfully used for creation of new highly effective NSAIDs, and also for modification of structures of known NSAIDs for the increase of effectiveness of their anti-inflammatory action.[PUBLICATION ABSTRACT]
ISSN:1990-7508
1990-7516
DOI:10.1134/S199075080704004X