Inhibition of Human Blood Acetylcholinesterase and Butyrylcholinesterase by Some Alkaloids

A comparative study has been carried out on effects of berberine (diisoquinoline alkaloid) and sanguinarine and chelidonine (benzophenanthridine alkaloids( on erythrocyte acetylcholinesterase and serum butyrylcholinesterase from human blood. The studied alkaloids have been shown to be strong reversi...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology 2002-01, Vol.38 (1), p.35
Main Authors: Kuznetsova, L P, Nikol'skaya, E B, Sochilina, E E, Faddeeva, M D
Format: Article
Language:English
Subjects:
Comparative studies
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Summary:A comparative study has been carried out on effects of berberine (diisoquinoline alkaloid) and sanguinarine and chelidonine (benzophenanthridine alkaloids( on erythrocyte acetylcholinesterase and serum butyrylcholinesterase from human blood. The studied alkaloids have been shown to be strong reversible inhibitors of the cholinesterase activity. Acetylcholinesterase is more sensitive to their action, than butyrylcholinesterase. The type of reversible inhibition was determined, and inhibitor constants were calculated. It is revealed that the character of inhibition is identical for the both cholinesterases. Berberine and sanguinarine are competitive-noncompetitive inhibitors, whereas chelidonine, a competitive inhibitor.[PUBLICATION ABSTRACT]
ISSN:0022-0930
1608-3202
DOI:10.1023/A:1015561103682