Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage: a rare adverse effect of sunitinib

We report the case of a 67-year-old man with metastatic papillary renal cell carcinoma (RCC) who developed bloody sputum after the administration of sunitinib. Chest computed tomography revealed diffuse ground-glass opacity lesions, and bloody bronchoalveolar lavage fluid was obtained by flexible br...

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Bibliographic Details
Published in:International journal of clinical oncology 2010-12, Vol.15 (6), p.638-641
Main Authors: Yamada, Tadaaki, Ohtsubo, Koushiro, Izumi, Kouji, Takeuchi, Shinji, Mouri, Hisatsugu, Yamashita, Kaname, Yasumoto, Kazuo, Ghenev, Peter, Kitagawa, Satoshi, Yano, Seiji
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Agents - adverse effects
Bronchoalveolar Lavage Fluid
Cancer Research
Carcinoma, Renal Cell - complications
Carcinoma, Renal Cell - drug therapy
Carcinoma, Renal Cell - secondary
Case Report
Cells
Drug therapy
Hemorrhage
Hemorrhage - chemically induced
Hemorrhage - pathology
Humans
Indoles - adverse effects
Kidney diseases
Kidney Neoplasms - complications
Kidney Neoplasms - drug therapy
Kidney Neoplasms - secondary
Lung Neoplasms - drug therapy
Lung Neoplasms - pathology
Male
Medicine
Medicine & Public Health
Oncology
Pulmonary Alveoli - drug effects
Pulmonary Alveoli - pathology
Pyrroles - adverse effects
Side effects
Surgical Oncology
Tomography, X-Ray Computed
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Summary:We report the case of a 67-year-old man with metastatic papillary renal cell carcinoma (RCC) who developed bloody sputum after the administration of sunitinib. Chest computed tomography revealed diffuse ground-glass opacity lesions, and bloody bronchoalveolar lavage fluid was obtained by flexible bronchoscopy. The abnormal shadows promptly regressed after withdrawal of sunitinib. In four cycles of sunitinib treatment, he suffered from controllable diffuse alveolar hemorrhage. Finally, he died of respiratory failure 8 months after onset. This is the first case report of diffuse alveolar hemorrhage as an adverse effect of sunitinib in metastatic papillary RCC. Care should be taken with pulmonary hemorrhage in the use of anti-angiogenesis agents in not only squamous cell lung cancer, but also metastatic lung tumors.
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-010-0104-3