Altered transcription and replication are the mechanisms of cytotoxicity of antitumor antibiotic olivomycin A

This study reports the effects of olivomycin A on gene expression and DNA synthesis in HCT116 human colon carcinoma cell line. The results provide evidence that olivomycin A is a genome wide inhibitor of gene transcription. This agent should be added to the list of compounds known to cause transcrip...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2010-12, Vol.435 (1), p.320-322
Main Authors: Cheglakov, I. B., Tevyashova, A. N., Kurbatov, L. K., Tatarsky, V. V., Samusenko, A. V., Preobrazhenskaya, M. N., Shtil, A. A.
Format: Article
Language:English
Subjects:
Antibiotics
Antibiotics, Antineoplastic - pharmacology
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Cellular biology
Colorectal cancer
Deoxyribonucleic acid
DNA
DNA Replication - drug effects
Gene expression
Gene Expression Regulation, Neoplastic - drug effects
HCT116 Cells
Humans
Life Sciences
Olivomycins - pharmacology
Pharmaceutical sciences
Proto-Oncogene Proteins c-myc - metabolism
Transcription, Genetic - drug effects
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Summary:This study reports the effects of olivomycin A on gene expression and DNA synthesis in HCT116 human colon carcinoma cell line. The results provide evidence that olivomycin A is a genome wide inhibitor of gene transcription. This agent should be added to the list of compounds known to cause transcriptional stress.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672910060104