Risk factors for nontraumatic osteonecrosis of the femoral head after renal transplantation

We investigated risk factors for osteonecrosis of the femoral head (ONF) in renal transplant recipients, who are susceptible to the disease. Among 287 renal transplant recipients, 18 ONF patients with enough data were included, and 18 age- and sex-matched recipients without ONF were nominated as ref...

Full description

Saved in:
Bibliographic Details
Published in:Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2003, Vol.8 (6), p.751-756
Main Authors: INOUE, Shigehiro, HORII, Motoyuki, KUBO, Toshikazu, ASANO, Takeshi, FUJIOKA, Mikihiro, OGURA, Taku, SHIBATANI, Masahiko, KIM, Wook-Choel, NAKAGAWA, Masako, TANAKA, Takashi, HIROTA, Yoshio
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Biological and medical sciences
Case-Control Studies
Combined surgery. Multiple transplantations
Female
Femur Head Necrosis - epidemiology
Femur Head Necrosis - etiology
Follow-Up Studies
Health risk assessment
Humans
Incidence
Kidney Transplantation - adverse effects
Kidney Transplantation - methods
Logistic Models
Male
Medical sciences
Middle Aged
Odds Ratio
Prednisolone - adverse effects
Prednisolone - therapeutic use
Probability
Risk Factors
Severity of Illness Index
Sex Distribution
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Transplantation Immunology
Transplants & implants
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated risk factors for osteonecrosis of the femoral head (ONF) in renal transplant recipients, who are susceptible to the disease. Among 287 renal transplant recipients, 18 ONF patients with enough data were included, and 18 age- and sex-matched recipients without ONF were nominated as reference cases. Risk factors were analyzed using a conditional logistic regression method. There were no differences between the ONF patients and the reference cases regarding the types of immunosuppressant or the donor (living or cadaveric, father or mother, matching blood type and human leukocyte antigens). The daily oral steroid dosage (prednisolone 25.0 mg/day or more) and blood urea nitrogen level 2 months after transplantation were the only factors with relevance to the occurrence of ONF. We propose that oral steroid dosages should be low or reduced after renal transplantation, and acute rejection should be controlled with pulsed therapy.
ISSN:0949-2658
1436-2023
DOI:10.1007/s00776-003-0716-9