A Portable Wireless Online Closed-Loop Seizure Controller in Freely Moving Rats

A considerable portion of epilepsy cannot be well treated by available therapies nowadays. Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative. A portable wireless online closed-loop seizure controller in freely moving rats was dev...

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Bibliographic Details
Published in:IEEE transactions on instrumentation and measurement 2011-02, Vol.60 (2), p.513-521
Main Authors: Young, Chung-Ping, Liang, Sheng-Fu, Chang, Da-Wei, Liao, Yi-Cheng, Shaw, Fu-Zen, Hsieh, Chao-Hsien
Format: Article
Language:English
Subjects:
Brain stimulation
Closed-loop
Costs
Delay
electroencephalogram (EEG)
Energy consumption
Epilepsy
Medical treatment
online
Rats
seizure
Sleep
wireless
Wireless communication
Wireless communications
Wires
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Summary:A considerable portion of epilepsy cannot be well treated by available therapies nowadays. Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative. A portable wireless online closed-loop seizure controller in freely moving rats was developed and shown with several aspects of advantages, including the following: 1) high accuracy of real-time seizure detection (92-99% during wake-sleep states); 2) low cost; and 3) low power consumption. The seizure detection latency was not greater than 0.6 s after seizure onset. A wireless communication feature also provided flexibility for subjects freeing from the hassle of wires. The observation showed that the stimulation elicited no abnormal behavior and had no sleep interruption to the subjects. The experiment data supported the functional possibility of a real-time closed-loop seizure controller.
ISSN:0018-9456
1557-9662
DOI:10.1109/TIM.2010.2050358