LT[Beta]R signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8+ T cells

During an immune response, antigen-bearing dendritic cells (DCs) migrate to the local draining lymph node and present antigen to CD4+ helper T cells. Antigen-activated CD4+ T cells then up-regulate TNF superfamily members including CD40 ligand and lymphotoxin (LT)αβ. Although it is well-accepted tha...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2011-02, Vol.108 (5), p.2046
Main Authors: deLuca, Leslie Summers, Ng, Dennis, Gao, Yunfei, Wortzman, Michael E, Watts, Tania H, Gommerman, Jennifer L
Format: Article
Language:English
Subjects:
Antigens
Immune response
Immunology
Licensing
Lymphatic system
T cell receptors
TNF inhibitors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:During an immune response, antigen-bearing dendritic cells (DCs) migrate to the local draining lymph node and present antigen to CD4+ helper T cells. Antigen-activated CD4+ T cells then up-regulate TNF superfamily members including CD40 ligand and lymphotoxin (LT)αβ. Although it is well-accepted that CD40 stimulation on DCs is required for DC licensing and cross-priming of CD8+ T-cell responses, it is likely that other signals are integrated into a comprehensive DC activation program. Here we show that a cognate interaction between LTαβ on CD4+ helper T cells and LTβ receptor on DCs results in unique signals that are necessary for optimal CD8+ T-cell expansion via a type I IFN-dependent mechanism. In contrast, CD40 signaling appears to be more critical for CD8+ T-cell IFN... production. Therefore, different TNF family members provide integrative signals that shape the licensing potential of antigen-presenting DCs. (ProQuest: ... denotes formulae/symbols omitted.)
ISSN:0027-8424
1091-6490