Urinary catalytic iron in patients with type 2 diabetes without microalbuminuria--a substudy of the ACCORD Trial

Participants were in different stages ofDM.Noneof the traditional risk factors (highly prevalent in this population) were associated with increased urinary catalytic iron in participants without microalbuminuria. [...] if urinary catalytic iron is associated with future cardiovascular or renal event...

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Published in:Clinical chemistry (Baltimore, Md.) Md.), 2011-02, Vol.57 (2), p.341-344
Main Authors: Thethi, Tina, Rajapurkar, Mohan, Walker, Patrick, McDuffie, Roberta, Goff, Jr, David C, Probstfield, Jeffrey, Yau, C Lillian, Shah, Sudhir, Christians, Uwe, Buse, John, Fonseca, Vivian
Format: Article
Language:English
Subjects:
Albuminuria - etiology
Albuminuria - prevention & control
Biomarkers - urine
Body mass index
Cross-Sectional Studies
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - urine
Female
Health sciences
Humans
Iron
Iron - urine
Isoprostanes - urine
Longitudinal studies
Male
Mass spectrometry
Middle Aged
Mortality
Oxidative Stress
Prevalence
Reference Values
Risk factors
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Summary:Participants were in different stages ofDM.Noneof the traditional risk factors (highly prevalent in this population) were associated with increased urinary catalytic iron in participants without microalbuminuria. [...] if urinary catalytic iron is associated with future cardiovascular or renal events, that association is likely to be independent of the covariates we examined. Because catalytic iron potentially provides a direct target for a therapeutic intervention, we recommend that longitudinal studies be conducted to examine the potential role of urinary catalytic iron in identifying patients at risk for incident renal and cardiovascular events.
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2010.155887