Menopause: clustering of metabolic syndrome components and population changes in insulin resistance

Aim The incidence of the metabolic syndrome (MS) in women rises rapidly during the menopause, substantially increasing their cardiovascular risk and mortality. The aim of the study was to analyze menopausal changes in individual MS components and the parameter of insulin resistance (HOMA-IR). Method...

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Bibliographic Details
Published in:Climacteric : the journal of the International Menopause Society 2011-02, Vol.14 (1), p.83-91
Main Authors: Lejsková, M, Alušík, S, Suchánek, M, Zecová, S, Pitha, J
Format: Article
Language:English
Subjects:
BLOOD PRESSURE
CARDIOVASCULAR DISEASE
CENTRAL OBESITY
Cholesterol, HDL - blood
Czech Republic - epidemiology
DYSLIPIDEMIA
Epidemiology
Female
Humans
Insulin
INSULIN RESISTANCE
MENOPAUSE
METABOLIC SYNDROME
Metabolic Syndrome - epidemiology
Middle Aged
Mortality
Obesity, Abdominal - epidemiology
Reproductive health
Risk factors
Triglycerides - blood
Waist Circumference
Womens health
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Summary:Aim The incidence of the metabolic syndrome (MS) in women rises rapidly during the menopause, substantially increasing their cardiovascular risk and mortality. The aim of the study was to analyze menopausal changes in individual MS components and the parameter of insulin resistance (HOMA-IR). Methods A random population sample of 909 women aged 45-54 years, resident in Prague 4, was examined in an epidemiological study. After excluding women with gynecological hormone therapy or surgical therapy, the two groups of women were compared: women of reproductive age (REPRO, n == 245) vs. naturally postmenopausal women (POSTm, n == 149). Results The incidence of MS rose significantly in menopause (REPRO/POSTm 22.9 ± 2.6%%/38.3 ± 4.0%%; p 
ISSN:1369-7137
1473-0804
DOI:10.3109/13697131003692745