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Menopause: clustering of metabolic syndrome components and population changes in insulin resistance
Aim The incidence of the metabolic syndrome (MS) in women rises rapidly during the menopause, substantially increasing their cardiovascular risk and mortality. The aim of the study was to analyze menopausal changes in individual MS components and the parameter of insulin resistance (HOMA-IR). Method...
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| Published in: | Climacteric : the journal of the International Menopause Society 2011-02, Vol.14 (1), p.83-91 |
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| container_title | Climacteric : the journal of the International Menopause Society |
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| creator | Lejsková, M Alušík, S Suchánek, M Zecová, S Pitha, J |
| description | Aim The incidence of the metabolic syndrome (MS) in women rises rapidly during the menopause, substantially increasing their cardiovascular risk and mortality. The aim of the study was to analyze menopausal changes in individual MS components and the parameter of insulin resistance (HOMA-IR).
Methods A random population sample of 909 women aged 45-54 years, resident in Prague 4, was examined in an epidemiological study. After excluding women with gynecological hormone therapy or surgical therapy, the two groups of women were compared: women of reproductive age (REPRO, n == 245) vs. naturally postmenopausal women (POSTm, n == 149).
Results The incidence of MS rose significantly in menopause (REPRO/POSTm 22.9 ± 2.6%%/38.3 ± 4.0%%; p |
| doi_str_mv | 10.3109/13697131003692745 |
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Methods A random population sample of 909 women aged 45-54 years, resident in Prague 4, was examined in an epidemiological study. After excluding women with gynecological hormone therapy or surgical therapy, the two groups of women were compared: women of reproductive age (REPRO, n == 245) vs. naturally postmenopausal women (POSTm, n == 149).
Results The incidence of MS rose significantly in menopause (REPRO/POSTm 22.9 ± 2.6%%/38.3 ± 4.0%%; p < 0.001). However, a detailed analysis among the five components defining MS showed that increases were only seen in waist circumference (p < 0.0001) and triglycerides (p < 0.001). There was no increase in the other components or HOMA-IR. A detailed analysis showed an increase in HOMA-IR at levels above the median (REPRO/POSTm: low HOMA-IR 0.9/0.9, not significant; high HOMA-IR 1.8/2.1, p < 0.001) and an increase in the incidence of MS just in these high levels of HOMA-IR and those rising during menopause (REPRO/POSTm: low HOMA-IR 13.8%%/18.7%%, not significant; high HOMA-IR 30.9%%/57.3%%, p < 0.0001). In menopause, there was an increase in the clustered incidence (accompanying MS) of each of the five MS components at the expense of isolated incidence (not accompanying MS).
Conclusion The acceleration of MS incidence at the onset of menopause may be accompanied by an increase in insulin resistance only in the population at highest risk. Reproductive women entering the menopause with an isolated MS component are at high risk for developing additional risk factors during menopause.</description><identifier>ISSN: 1369-7137</identifier><identifier>EISSN: 1473-0804</identifier><identifier>DOI: 10.3109/13697131003692745</identifier><identifier>PMID: 20443721</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>BLOOD PRESSURE ; CARDIOVASCULAR DISEASE ; CENTRAL OBESITY ; Cholesterol, HDL - blood ; Czech Republic - epidemiology ; DYSLIPIDEMIA ; Epidemiology ; Female ; Humans ; Insulin ; INSULIN RESISTANCE ; MENOPAUSE ; METABOLIC SYNDROME ; Metabolic Syndrome - epidemiology ; Middle Aged ; Mortality ; Obesity, Abdominal - epidemiology ; Reproductive health ; Risk factors ; Triglycerides - blood ; Waist Circumference ; Womens health</subject><ispartof>Climacteric : the journal of the International Menopause Society, 2011-02, Vol.14 (1), p.83-91</ispartof><rights>2011 International Menopause Society 2011</rights><rights>Copyright Taylor & Francis Ltd. Feb 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-aaad91690db1f37735218f9fc07ff01aee93a27e2cb933b3f831da3d14d632493</citedby><cites>FETCH-LOGICAL-c498t-aaad91690db1f37735218f9fc07ff01aee93a27e2cb933b3f831da3d14d632493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20443721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lejsková, M</creatorcontrib><creatorcontrib>Alušík, S</creatorcontrib><creatorcontrib>Suchánek, M</creatorcontrib><creatorcontrib>Zecová, S</creatorcontrib><creatorcontrib>Pitha, J</creatorcontrib><title>Menopause: clustering of metabolic syndrome components and population changes in insulin resistance</title><title>Climacteric : the journal of the International Menopause Society</title><addtitle>Climacteric</addtitle><description>Aim The incidence of the metabolic syndrome (MS) in women rises rapidly during the menopause, substantially increasing their cardiovascular risk and mortality. The aim of the study was to analyze menopausal changes in individual MS components and the parameter of insulin resistance (HOMA-IR).
Methods A random population sample of 909 women aged 45-54 years, resident in Prague 4, was examined in an epidemiological study. After excluding women with gynecological hormone therapy or surgical therapy, the two groups of women were compared: women of reproductive age (REPRO, n == 245) vs. naturally postmenopausal women (POSTm, n == 149).
Results The incidence of MS rose significantly in menopause (REPRO/POSTm 22.9 ± 2.6%%/38.3 ± 4.0%%; p < 0.001). However, a detailed analysis among the five components defining MS showed that increases were only seen in waist circumference (p < 0.0001) and triglycerides (p < 0.001). There was no increase in the other components or HOMA-IR. A detailed analysis showed an increase in HOMA-IR at levels above the median (REPRO/POSTm: low HOMA-IR 0.9/0.9, not significant; high HOMA-IR 1.8/2.1, p < 0.001) and an increase in the incidence of MS just in these high levels of HOMA-IR and those rising during menopause (REPRO/POSTm: low HOMA-IR 13.8%%/18.7%%, not significant; high HOMA-IR 30.9%%/57.3%%, p < 0.0001). In menopause, there was an increase in the clustered incidence (accompanying MS) of each of the five MS components at the expense of isolated incidence (not accompanying MS).
Conclusion The acceleration of MS incidence at the onset of menopause may be accompanied by an increase in insulin resistance only in the population at highest risk. Reproductive women entering the menopause with an isolated MS component are at high risk for developing additional risk factors during menopause.</description><subject>BLOOD PRESSURE</subject><subject>CARDIOVASCULAR DISEASE</subject><subject>CENTRAL OBESITY</subject><subject>Cholesterol, HDL - blood</subject><subject>Czech Republic - epidemiology</subject><subject>DYSLIPIDEMIA</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin</subject><subject>INSULIN RESISTANCE</subject><subject>MENOPAUSE</subject><subject>METABOLIC SYNDROME</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Obesity, Abdominal - epidemiology</subject><subject>Reproductive health</subject><subject>Risk factors</subject><subject>Triglycerides - blood</subject><subject>Waist Circumference</subject><subject>Womens health</subject><issn>1369-7137</issn><issn>1473-0804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kEFrFTEUhYMotn36A9xIcONqNJnkvUy0GylWhYobXQ93kpu-lEwyJhnk_XtTXlVUChfu4fKdQ3IIecbZK8GZfs3FTiveJGuiV3L7gJxyqUTHBiYfNt3OXQPUCTkr5YYxLgTfPSYnPZNSqJ6fEvMZY1pgLfiGmrCWitnHa5ocnbHClII3tByizWlGatK8pIixFgrR0iUta4DqU6RmD_EaC_WxTVlD2xmLLxWiwSfkkYNQ8Ond3pBvl--_Xnzsrr58-HTx7qozUg-1AwCr-U4zO3EnlBLbng9OO8OUc4wDohbQK-zNpIWYhBsEtyAsl3YneqnFhrw85i45fV-x1HH2xWAIEDGtZRykkJwPrYUNefEPeZPWHNvjxmErtlpJphrEj5DJqZSMblyynyEfRs7G2_7H__pvnud3wes0o_3t-FV4A86PgI8u5Rl-pBzsWOEQUna5teXLbfb9-W__su8RQt0byPjnB_e7fwJ_vqaL</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Lejsková, M</creator><creator>Alušík, S</creator><creator>Suchánek, M</creator><creator>Zecová, S</creator><creator>Pitha, J</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201102</creationdate><title>Menopause: clustering of metabolic syndrome components and population changes in insulin resistance</title><author>Lejsková, M ; Alušík, S ; Suchánek, M ; Zecová, S ; Pitha, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-aaad91690db1f37735218f9fc07ff01aee93a27e2cb933b3f831da3d14d632493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>BLOOD PRESSURE</topic><topic>CARDIOVASCULAR DISEASE</topic><topic>CENTRAL OBESITY</topic><topic>Cholesterol, HDL - blood</topic><topic>Czech Republic - epidemiology</topic><topic>DYSLIPIDEMIA</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin</topic><topic>INSULIN RESISTANCE</topic><topic>MENOPAUSE</topic><topic>METABOLIC SYNDROME</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Obesity, Abdominal - epidemiology</topic><topic>Reproductive health</topic><topic>Risk factors</topic><topic>Triglycerides - blood</topic><topic>Waist Circumference</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lejsková, M</creatorcontrib><creatorcontrib>Alušík, S</creatorcontrib><creatorcontrib>Suchánek, M</creatorcontrib><creatorcontrib>Zecová, S</creatorcontrib><creatorcontrib>Pitha, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Climacteric : the journal of the International Menopause Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lejsková, M</au><au>Alušík, S</au><au>Suchánek, M</au><au>Zecová, S</au><au>Pitha, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Menopause: clustering of metabolic syndrome components and population changes in insulin resistance</atitle><jtitle>Climacteric : the journal of the International Menopause Society</jtitle><addtitle>Climacteric</addtitle><date>2011-02</date><risdate>2011</risdate><volume>14</volume><issue>1</issue><spage>83</spage><epage>91</epage><pages>83-91</pages><issn>1369-7137</issn><eissn>1473-0804</eissn><abstract>Aim The incidence of the metabolic syndrome (MS) in women rises rapidly during the menopause, substantially increasing their cardiovascular risk and mortality. The aim of the study was to analyze menopausal changes in individual MS components and the parameter of insulin resistance (HOMA-IR).
Methods A random population sample of 909 women aged 45-54 years, resident in Prague 4, was examined in an epidemiological study. After excluding women with gynecological hormone therapy or surgical therapy, the two groups of women were compared: women of reproductive age (REPRO, n == 245) vs. naturally postmenopausal women (POSTm, n == 149).
Results The incidence of MS rose significantly in menopause (REPRO/POSTm 22.9 ± 2.6%%/38.3 ± 4.0%%; p < 0.001). However, a detailed analysis among the five components defining MS showed that increases were only seen in waist circumference (p < 0.0001) and triglycerides (p < 0.001). There was no increase in the other components or HOMA-IR. A detailed analysis showed an increase in HOMA-IR at levels above the median (REPRO/POSTm: low HOMA-IR 0.9/0.9, not significant; high HOMA-IR 1.8/2.1, p < 0.001) and an increase in the incidence of MS just in these high levels of HOMA-IR and those rising during menopause (REPRO/POSTm: low HOMA-IR 13.8%%/18.7%%, not significant; high HOMA-IR 30.9%%/57.3%%, p < 0.0001). In menopause, there was an increase in the clustered incidence (accompanying MS) of each of the five MS components at the expense of isolated incidence (not accompanying MS).
Conclusion The acceleration of MS incidence at the onset of menopause may be accompanied by an increase in insulin resistance only in the population at highest risk. Reproductive women entering the menopause with an isolated MS component are at high risk for developing additional risk factors during menopause.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>20443721</pmid><doi>10.3109/13697131003692745</doi><tpages>9</tpages></addata></record> |
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| subjects | BLOOD PRESSURE CARDIOVASCULAR DISEASE CENTRAL OBESITY Cholesterol, HDL - blood Czech Republic - epidemiology DYSLIPIDEMIA Epidemiology Female Humans Insulin INSULIN RESISTANCE MENOPAUSE METABOLIC SYNDROME Metabolic Syndrome - epidemiology Middle Aged Mortality Obesity, Abdominal - epidemiology Reproductive health Risk factors Triglycerides - blood Waist Circumference Womens health |
| title | Menopause: clustering of metabolic syndrome components and population changes in insulin resistance |
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