In Vivo Mapping of Brain Elasticity in Small Animals Using Shear Wave Imaging

A combination of radiation force and ultrafast ultra-sound imaging is used to both generate and track the propagation of a shear wave in the brain whose local speed is directly related to stiffness, characterized by the dynamic shear modulus G*. When performed on trepanated rats, this approach calle...

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Bibliographic Details
Published in:IEEE transactions on medical imaging 2011-03, Vol.30 (3), p.550-558
Main Authors: Macé, E, Cohen, I, Montaldo, G, Miles, R, Fink, M, Tanter, M
Format: Article
Language:English
Subjects:
Acoustics
Algorithms
Animals
Anisotropy
Brain
Brain - physiology
Echoencephalography - methods
Elastic Modulus - physiology
Elasticity
Elasticity Imaging Techniques - methods
Elasticity Imaging Techniques - veterinary
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging
Probes
Propagation
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Sensitivity and Specificity
Shear Strength - physiology
shear wave imaging (SWI)
Three dimensional displays
Ultrasonic imaging
ultrasound
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Summary:A combination of radiation force and ultrafast ultra-sound imaging is used to both generate and track the propagation of a shear wave in the brain whose local speed is directly related to stiffness, characterized by the dynamic shear modulus G*. When performed on trepanated rats, this approach called shear wave imaging (SWI) provides 3-D brain elasticity maps reaching a spatial resolution of 0.7 mm × 1 mm × 0.4 mm with a good reproducibility (
ISSN:0278-0062
1558-254X
DOI:10.1109/TMI.2010.2079940