Simple and Efficient Method for Synthesis of Bis(indolyl) Methanes with Cu(BF4)2·SiO2 Under Mild Conditions

A simple and efficient synthesis of bis(indolyl) methanes by the reaction of indoles with various carbonyl compounds in the presence of a catalytic amount of cupric fluoroborate [Cu(BF 4 ) 2 ·SiO 2 ] afforded the corresponding bis(indolyl) methanes in excellent yields. The remarkable selectivity und...

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Published in:Synthetic communications 2010-01, Vol.40 (1), p.29-38
Main Authors: Meshram, G. A., Patil, Vishvanath D.
Format: Article
Language:English
Subjects:
Bis(indolyl) methanes
cupric fluoroborate
dichloromethane
indole
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description A simple and efficient synthesis of bis(indolyl) methanes by the reaction of indoles with various carbonyl compounds in the presence of a catalytic amount of cupric fluoroborate [Cu(BF 4 ) 2 ·SiO 2 ] afforded the corresponding bis(indolyl) methanes in excellent yields. The remarkable selectivity under mild and neutral conditions and commercially available, inexpensive catalyst are attractive features of this method.
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source Taylor and Francis Science and Technology Collection
subjects Bis(indolyl) methanes
cupric fluoroborate
dichloromethane
indole
title Simple and Efficient Method for Synthesis of Bis(indolyl) Methanes with Cu(BF4)2·SiO2 Under Mild Conditions
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