Green, One-Pot, Solvent-Free Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles Using a Brønsted Acidic Ionic Liquid as Novel and Reusable Catalyst

3-Methyl-1-(4-sulfonic acid)butylimidazolium hydrogen sulfate [(CH 2 ) 4 SO 3 HMIM][HSO 4 ], a Brønsted acidic ionic liquid, has been used as an efficient, green, and reusable catalyst for the synthesis of 1,2,4,5-tetrasubstituted imidazoles using benzil, an aromatic aldehyde, and a primary amine in...

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Bibliographic Details
Published in:Synthetic communications 2010-08, Vol.40 (17), p.2588-2597
Main Authors: Davoodnia, Abolghasem, Heravi, Majid M., Safavi-Rad, Zahra, Tavakoli-Hoseini, Niloofar
Format: Article
Language:English
Subjects:
Brønsted acidic ionic liquids
multicomponent reactions
one-pot synthesis
solvent-free conditions
tetrasubstituted imidazole
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Summary:3-Methyl-1-(4-sulfonic acid)butylimidazolium hydrogen sulfate [(CH 2 ) 4 SO 3 HMIM][HSO 4 ], a Brønsted acidic ionic liquid, has been used as an efficient, green, and reusable catalyst for the synthesis of 1,2,4,5-tetrasubstituted imidazoles using benzil, an aromatic aldehyde, and a primary amine in the presence of ammonium acetate under solvent-free conditions. The catalyst could be recycled and reused several times without noticeably decreasing the catalytic activity.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910903289271