Rapid and Convenient Thermal or Microwave-Assisted Synthesis of Substituted 2-Phenylbenzothiazoles

A simple one-step method for the synthesis of biologically relevant 2-phenylbenzothiazoles has been developed, using sodium metabisulfite as an oxidant following condensation between 2-aminothiophenol and substituted benzaldehydes. Attractive features of this new method include excellent yields unde...

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Bibliographic Details
Published in:Synthetic communications 2010-09, Vol.40 (20), p.3027-3032
Main Authors: Weekes, Ashley A., Dix, Matthew C., Bagley, Mark C., Westwell, Andrew D.
Format: Article
Language:English
Subjects:
2-phenylbenzothiazoles
Antitumor agents
bicyclic compounds
heterocycles
microwave synthesis
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Summary:A simple one-step method for the synthesis of biologically relevant 2-phenylbenzothiazoles has been developed, using sodium metabisulfite as an oxidant following condensation between 2-aminothiophenol and substituted benzaldehydes. Attractive features of this new method include excellent yields under both microwave-assisted or thermal conditions (it is tolerant of a variety of substituents on the phenyl ring) and simple product isolation without the need for chromatographic purification.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910903353739