The Correlation Between Bubble-Enhanced HIFU Heating and Cavitation Power

It has been established that while the inherent presence of bubbles increases heat generation due to scattering and absorption, inertial cavitation is responsible for elevated heating during high-intensity focused ultrasound (HIFU) application. The contribution of bubble-induced heating can be an im...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2010-01, Vol.57 (1), p.175-184
Main Authors: Farny, Caleb H., Glynn Holt, R., Roy, Ronald A.
Format: Article
Language:English
Subjects:
Absorption
Acoustic scattering
Algorithms
Bubbles
Cavitation
Cavitation diagnostics
Correlation
Detectors
Electric potential
Heating
high-intensity focused ultrasound (HIFU)
High-Intensity Focused Ultrasound Ablation - methods
Hot Temperature
Imaging phantoms
Inertial
inertial cavitation
Microbubbles
passive cavitation detection (PCD)
Phantoms, Imaging
Signal processing
Signal Processing, Computer-Assisted
Temperature measurement
Ultrasonic imaging
Ultrasonic variables measurement
Ultrasound
Voltage
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Summary:It has been established that while the inherent presence of bubbles increases heat generation due to scattering and absorption, inertial cavitation is responsible for elevated heating during high-intensity focused ultrasound (HIFU) application. The contribution of bubble-induced heating can be an important factor to consider, as it can be several times greater than the expected heat deposition from absorption of energy from the primary ultrasound field. The temperature and cavitation signal near the focus were measured for 5.5-s continuous-wave 1.1-MHz HIFU sonications in tissue mimicking phantoms. The measured temperature was corrected for heating predicted from the primary ultrasound absorption to isolate the temperature rise from the bubble activity. The temperature rise induced from cavitation correlates well with a measurement of the instantaneous ¿cavitation power¿ as indicated by the mean square voltage output of a 15-MHz passive cavitation detector. The results suggest that careful processing of the cavitation signals can serve as a proxy for measuring the heating contribution from inertial cavitation.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2009.2028133