Cameroonemide A: a new ceramide from Helichrysum cameroonense

From the extracts of all parts of the plant Helichrysum cameroonense, five compounds were isolated and identified. One of them, a ceramide, named cameroonemide A (1), is reported for the first time as a new natural product. Its structure was determined by comprehensive analyses of their 1D and 2D NM...

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Bibliographic Details
Published in:Journal of asian natural products research 2010-07, Vol.12 (7), p.629-633
Main Authors: Antoine, Kakam Zanetsie, Hussain, Hidayat, Dongo, Etienne, Kouam, Simeon F., Schulz, Barbara, Krohn, Karsten
Format: Article
Language:English
Subjects:
Acids
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
antimicrobial activity
Asteraceae
Bacillus megaterium - drug effects
Bacteria
Biological and medical sciences
Cameroon
ceramide
Ceramides - chemistry
Ceramides - isolation & purification
Ceramides - pharmacology
General pharmacology
Helichrysum - chemistry
Helichrysum cameroonense
Medical sciences
Microbial Sensitivity Tests
Molecular Structure
Natural products
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
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Summary:From the extracts of all parts of the plant Helichrysum cameroonense, five compounds were isolated and identified. One of them, a ceramide, named cameroonemide A (1), is reported for the first time as a new natural product. Its structure was determined by comprehensive analyses of their 1D and 2D NMR and HR-EI-MS spectral data. The remaining four known compounds were identified by comparing their spectroscopic data with those reported in the literature as kaurenoic acid (2), 3-acetyloxykaurenoic acid (3), β-sitosterol (4), and β-sitosterol glucopyranoside (5). Preliminary studies showed that 3-acetyloxykaurenoic acid (3) inhibited the alga Chlorella fusca, while kaurenoic acid (2) showed strong antibacterial activity against Bacillus megaterium.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2010.485933