In vitro study of lipid peroxidation and free radical scavenging activity of cow urine

This study represents a comprehensive analysis and scientific validation of our ancient knowledge about the ethnopharmacological aspects of cow urine by measuring the lipid peroxidation, radical scavenging, and level of reduced glutathione and catalase activity. Graded doses of cow urine were admini...

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Bibliographic Details
Published in:European food research & technology 2011-04, Vol.232 (4), p.703-711
Main Authors: Lavania, Meeta, Dalal, Jyotsana, Cheema, Simrita, Nautiyal, Chandra Shekhar, Lal, Banwari
Format: Article
Language:English
Subjects:
1, 1-diphenyl-2-picrylhydrazyl
Agriculture
Ammonia
Analysis
Analytical Chemistry
Animal productions
Antioxidants
Biological and medical sciences
Biotechnology
catalase
Cattle
Chemistry
Chemistry and Materials Science
Chronic illnesses
Diet
Ethnomedicine
Food
Food industries
Food Science
Forestry
Free radicals
Fundamental and applied biological sciences. Psychology
glutathione
Lipid peroxidation
Lipids
Liver
Medical research
Medical treatment
Original Paper
Oxidative stress
Peroxidation
Plasma
Reagents
Studies
Terrestrial animal productions
thiobarbituric acid-reactive substances
Uric acid
Urine
Vertebrates
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Summary:This study represents a comprehensive analysis and scientific validation of our ancient knowledge about the ethnopharmacological aspects of cow urine by measuring the lipid peroxidation, radical scavenging, and level of reduced glutathione and catalase activity. Graded doses of cow urine were administered orally to experimentally treated rats. Results of liver and plasma from experimentally treated rats indicated that cow urine reduced the levels of thiobarbituric acid reactive substance significantly in all the treatments (P < 0.01). In vitro experiments with the liver of control and experimentally treated rats were also carried out against cumene hydroperoxide-induced lipid peroxidation. On LCMS analysis, the antioxidant component of cow urine was identified as uric acid (m/z 169.07). The results demonstrate that the cow urine-mediated induction of antioxidant level controls oxidative damage, even after minimal processing, and thus is indicative of its potential as a viable substitute of synthetic antioxidants.
ISSN:1438-2377
1438-2385
DOI:10.1007/s00217-011-1436-6