Review: Towards molecular imaging of multiple sclerosis

Magnetic resonance imaging (MRI) has had a profound impact on both research and clinical management of multiple sclerosis (MS), but signal changes reflect underlying neuropathology only indirectly and often non-specifically. Positron emission tomography (PET) offers the potential to complement MRI w...

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Bibliographic Details
Published in:Multiple sclerosis 2011-03, Vol.17 (3), p.262
Main Authors: Owen, David RJ, Piccini, Paola, Matthews, Paul M
Format: Article
Language:English
Online Access:Get full text
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Summary:Magnetic resonance imaging (MRI) has had a profound impact on both research and clinical management of multiple sclerosis (MS), but signal changes reflect underlying neuropathology only indirectly and often non-specifically. Positron emission tomography (PET) offers the potential to complement MRI with quantitative measures of molecularly specific markers of cellular and metabolic processes. PET radiotracers already available promise new insights into the dynamics of the innate immune response, neuronal function, neurodegeneration and remyelination. Because PET is an exquisitely sensitive technique (able to image even picomolar concentrations), only microdoses of radioligand (
ISSN:1477-0970
DOI:10.1177/1352458510390070