D2-40 p63 defined lymph vessel invasion has additional prognostic value in highly proliferating operable node negative breast cancer patients

• Published in: Modern pathology 2011-04, Vol.24 (4), p.502-511
• Main Authors: Gudlaugsson, Einar, Skaland, Ivar, Undersrud, Erling, Janssen, Emiel AM, Søiland, Håvard, Baak, Jan PA
• Format: Article
• Language: English
• Subjects: 692/699/67/1347; 692/699/67/1857; Age Factors; Aged; Antibodies, Monoclonal, Murine-Derived; Biomarkers, Tumor - analysis; Breast Neoplasms - chemistry; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Cell Proliferation; Female; Histones - analysis; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Laboratory Medicine; Lymph Node Excision; Lymphatic Vessels - chemistry; Lymphatic Vessels - pathology; Mastectomy; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Norway; original-article; Pathology; Phosphorylation; Predictive Value of Tests; Proportional Hazards Models; Radiotherapy, Adjuvant; Risk Assessment; Survival Rate; Time Factors; Transcription Factors - analysis; Treatment Outcome; Tumor Suppressor Proteins - analysis
• ISSN: 0893-3952; 1530-0285
• DOI: 10.1038/modpathol.2010.199

Phosphohistone H3 assessed proliferation has strong prognostic value. Lymph vessel invasion by D2-40 is also prognostic, but D2-40+ myoepithelial expression in small ducts completely filled by solid-pattern ductal carcinoma in situ can mimic lymphovascular invasion. As myoepithelial cells are also p63 positive, we have investigated whether lymph vessel invasion identified by combined D2-40/p63 is stronger prognostically than by D2-40 alone, and whether it has independent prognostic value to phosphohistone H3. In 240 operable T 1–2 N 0 M 0 node negative invasive breast cancer patients