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Radical scavenging and in vitro antifungal activities of Cu(II) and Co(II) complexes of the t-butylphenyl derivative of porphyrazine

Co(II) and Cu(II) complexes and metal-free t-butylphenyl peripherally substituted porphyrazine (Pz) have been screened for in vitro antifungal (Aspergillus niger) and antioxidant (free radical scavenging, superoxide radical scavenging, and reducing power) activities. The results were compared with s...

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Bibliographic Details
Published in:Journal of coordination chemistry 2010-11, Vol.63 (22), p.3999-4006
Main Authors: Keskin, Bahadir, Peksel, Aysegul, Avciata, Ulvi, Gül, Ahmet
Format: Article
Language:English
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Summary:Co(II) and Cu(II) complexes and metal-free t-butylphenyl peripherally substituted porphyrazine (Pz) have been screened for in vitro antifungal (Aspergillus niger) and antioxidant (free radical scavenging, superoxide radical scavenging, and reducing power) activities. The results were compared with synthetic antioxidants, e.g., butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), trolox, or α-tocopherol. The free radical scavenging activity of H 2 Pz was higher than the CuPz complex. However, CuPz complex showed higher superoxide radical scavenging activity than BHA, BHT, and trolox while H 2 Pz and CoPz showed weaker activity than BHA, BHT, and trolox. The reducing power of all complexes was similar to that of BHT and α-tocopherol on a per molar basis. The ligand and complexes have antifungal activity against A. niger. The compounds have significant superoxide radical scavenging activity against various antioxidant systems in vitro.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2010.524930