Micelles of PAAm-b-PEO-b-PAAm Triblock Copolymers and Their Binding with Prednisolon

The IntraPC forming asymmetric PAAm-b-PEO-b-PAAm triblock copolymers (TBCs) composed of poly(ethylene oxide) (... = 6 ... 10... and 1.4 ... 10...) and polyacrylamide of a variable chain length form "hairy-type" micelles in water and "flower-like" micelles at the addition of EtOH...

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Bibliographic Details
Published in:Molecular Crystals and Liquid Crystals 2011-02, Vol.536, p.380
Main Authors: Zheltonozhskaya, Tatyana, Nedashkovskaya, Victoria, Khutoryanskiy, Vitaliy, Gomza, Yuriy, Fedorchuk, Sergey, Klepko, Valeriy, Partsevskaya, Sofia
Format: Article
Language:English
Subjects:
Aqueous solutions
Copolymers
Crystal structure
Crystallization
Ethanol
Hydrogen bonds
Polyethylene
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Summary:The IntraPC forming asymmetric PAAm-b-PEO-b-PAAm triblock copolymers (TBCs) composed of poly(ethylene oxide) (... = 6 ... 10... and 1.4 ... 10...) and polyacrylamide of a variable chain length form "hairy-type" micelles in water and "flower-like" micelles at the addition of EtOH > 40 vol %. The specific micellization is developed in TBC aqueous/ethanol solutions (EtOH content < 30 vol %) at the PS introduction. It is caused by the binding of PS with TBC micelles due to hydrogen bonds and hydrophobic interactions. The amorphous structure of TBCs and polymorphic crystalline structures of PS are found. The products of the interaction of TBC and PS contain highly ordered crystalline structures of the drug. But it is possible to avoid the drug crystallization at low PS contents. (ProQuest: ... denotes formulae/symbols omitted.)
ISSN:1542-1406
1527-1943