Withanolides: Phytoconstituents with significant pharmacological activities

Withanolides are a group of naturally occurring oxygenated ergostane type steroids, having lactone in side chain and 2-en-1-one system in the ring. Withanolides are present in medicinal plants of Solanaceae family. Formulations based on these medicinal plants are widely used in Ayurveda and traditio...

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Published in:International journal of green pharmacy 2010-10, Vol.4 (4), p.229
Main Authors: Singh, Amritpal, Duggal, Sanjeev, Singh, Harmanpreet, Singh, Jaswinder, Katekhaye, Shankar
Format: Article
Language:English
Subjects:
Bioassays
Cancer
Chemical properties
Health aspects
Larynx
Materia medica, Vegetable
Medicine, Botanic
Medicine, Herbal
Plant extracts
Rodents
Solanaceae
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Summary:Withanolides are a group of naturally occurring oxygenated ergostane type steroids, having lactone in side chain and 2-en-1-one system in the ring. Withanolides are present in medicinal plants of Solanaceae family. Formulations based on these medicinal plants are widely used in Ayurveda and traditional Chinese medicine. Withanolides have shown a wide range of pharmacological activities including hypno¬sedative, immunomodulatory, anti-inflammatory, antiarthritic, angiogenesis inhibitor, anticholinesterase, antioxidant, antibacterial and above all, antitumour. Withaferin A is the best studied withanolide as far as pharmacological investigations are concerned. The present review summarises the investigative work carried out on bioactive withanolides.
ISSN:0973-8258
1998-4103
DOI:10.4103/0973-8258.74130