Eco-friendly polyethylene glycol-400: a rapid and efficient recyclable reaction medium for the synthesis of thiazole derivatives

An efficient and convenient procedure for the synthesis of thiazole derivatives from α-haloketone, thiourea and substituted acetophenones using polyethylene glycol-400 as a green and recyclable solvent is described. Significant rate enhancement and improved yields have been observed.

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Bibliographic Details
Published in:Green chemistry letters and reviews 2010-09, Vol.3 (3), p.205-208
Main Authors: Dawane, Bhaskar S., Shaikh, Baseer M., Khandare, Namdev T., Kamble, Vinod T., Chobe, Santosh S., Konda, Shankaraiah G.
Format: Article
Language:English
Subjects:
Derivatives
Green chemistry
polyethylene glycol
substituted acetophenones
thiazole derivatives
thiourea
α-haloketones
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Description
Summary:An efficient and convenient procedure for the synthesis of thiazole derivatives from α-haloketone, thiourea and substituted acetophenones using polyethylene glycol-400 as a green and recyclable solvent is described. Significant rate enhancement and improved yields have been observed.
ISSN:1751-8253
1751-7192
DOI:10.1080/17518251003709506