A Real-Time Exposure System for Electrophysiological Recording in Brain Slices

In order to study possible effects of microwave electromagnetic (EM) fields on neuronal activity, a real-time exposure system was designed and fabricated. The structure is suitable for electrophysiological recording in brain slices, a widely used in vitro methodology for investigations on neuronal f...

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Bibliographic Details
Published in:IEEE transactions on microwave theory and techniques 2007-11, Vol.55 (11), p.2463-2471
Main Authors: Paffi, A., Pellegrino, M., Beccherelli, R., Apollonio, F., Liberti, M., Platano, D., Aicardi, G., D'Inzeo, G.
Format: Article
Language:English
Subjects:
Applied sciences
Bioelectric phenomena
biological effects of microwaves
Brain
brain slices
Coplanar waveguides
Dosimetry
Electrodes
Electromagnetic compatibility
Electromagnetic fields
electrophysiological recordings
Exact sciences and technology
exposure system
Humans
In vitro
Information, signal and communications theory
Mathematical analysis
Mathematical models
Microwaves
Neurotransmitters
Physiology
Radio frequency
Real time
Real time systems
Recording
Services and terminals of telecommunications
Synthetic aperture radar
Systems, networks and services of telecommunications
Telecommunications
Telecommunications and information theory
Telephone. Videophone
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Description
Summary:In order to study possible effects of microwave electromagnetic (EM) fields on neuronal activity, a real-time exposure system was designed and fabricated. The structure is suitable for electrophysiological recording in brain slices, a widely used in vitro methodology for investigations on neuronal function. The EM features of the structure were characterized both numerically and experimentally. Results indicate that the system is slightly radiating and that its field configuration produces minimum coupling with laboratory equipment. To determine the device efficiency, numerical and experimental dosimetry was conducted. The system exhibits high efficiency, with uniform distribution of the E- and H-fields and the specific absorption rate (SAR) in the biological sample.
ISSN:0018-9480
1557-9670
DOI:10.1109/TMTT.2007.908657