Exploration of L-Proline-Catalyzed [alpha]-Aminoxylation of Aldehyde to (S)-Guaifenesin-Related Drug Molecules

An efficient enantioselective synthesis of (S)-guaifenesin with >99% ee using L-proline-catalyzed α-aminoxylation of aldehyde as key step is described and explored for asymmetric syntheses of (S)-moprolol and (R)-methocarbamol. [image omitted]

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Bibliographic Details
Published in:Synthetic communications 2011-07, Vol.41 (13), p.1938
Main Authors: Panchgalle, Sharad P, Kunte, Sunita S, Chavan, Subhash P, Kalkote, Uttam R
Format: Article
Language:English
Subjects:
Aldehydes
Online Access:Get full text
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Description
Summary:An efficient enantioselective synthesis of (S)-guaifenesin with >99% ee using L-proline-catalyzed α-aminoxylation of aldehyde as key step is described and explored for asymmetric syntheses of (S)-moprolol and (R)-methocarbamol. [image omitted]
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2010.493631