Detection of Hepatic Metastases Using Dual-Time-Point FDG PET/CT Scans in Patients with Colorectal Cancer

Purpose The purpose of this study was to determine the most useful parameter of dual-time-point 2-deoxy-2-[ 18 F]fluoro- d -glucose positron emission tomography/computed tomography (PET/CT) for detection of hepatic metastases in patients with colorectal cancer. Procedures Thirty-nine patients had un...

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Bibliographic Details
Published in:Molecular imaging and biology 2011-06, Vol.13 (3), p.565-572
Main Authors: Lee, Jeong Won, Kim, Seok-Ki, Lee, Sang Mi, Moon, Seung Hwan, Kim, Tae-Sung
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Colorectal Neoplasms - pathology
Contrast Media
Female
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Imaging
Liver - metabolism
Liver - pathology
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - secondary
Male
Medicine
Medicine & Public Health
Middle Aged
Positron-Emission Tomography
Radiology
Research Article
ROC Curve
Time Factors
Tomography, X-Ray Computed
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Summary:Purpose The purpose of this study was to determine the most useful parameter of dual-time-point 2-deoxy-2-[ 18 F]fluoro- d -glucose positron emission tomography/computed tomography (PET/CT) for detection of hepatic metastases in patients with colorectal cancer. Procedures Thirty-nine patients had undergone a dual-time-point PET/CT scan and a subsequent histopathological confirmation for a workup of hepatic metastases. Detection rates were compared for visual analysis score, standardized uptake value (SUV), tumor-to-liver uptake ratio (TLR), and percent changes of the SUV and TLR. Results Of 91 liver lesions, 86 lesions were confirmed as metastases. The SUV and TLR of metastatic lesions on the delayed images were higher than those on the first scan ( p  
ISSN:1536-1632
1860-2002
DOI:10.1007/s11307-010-0394-x